Please answer the following questions:
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use Attached document to answer the following questions: answer under the following labeled questions:
Question 1:
Discuss how PML-RARA fusion contributes to leukemogenesis. What is the typical clinical and laboratory presentation? What therapy is critical to initiate with this fusion and why?
Question 2 :
How is MRD monitored in AML and what are some of the related issues?
Question 3 :
Discuss the role of the core binding factor in leukemogenesis. Discuss the molecular mechanisms of two translocations involving CBF in AML.
Question 4 :
Describe tests used in the diagnosis of AML. What are some of the practice guidelines for diagnosis, prognosis, and monitoring of AML?
Question 5:
Describe some new treatments in AML that are in clinical development.
Question 6 :
Discuss some clinical issues in treating AML in older patients.
Question 7 :
What are leukemia stem cells and why are they so difficult to eradicate in AML?
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